MitoTracer identified essential primary BRAF inhibitor-resistant genes.
<p>(A)The reconstructed lineage was visualized by heatmap from MitoTracer. All these cells were clustered into two major clusters labeled “Cluster_1” and “Cluster_2”. Cells were labeled according to their original BRAF inhibitor resistance status, “Resistant” and “Parental”. We also labeled th...
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2025
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| _version_ | 1852019133956227072 |
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| author | Xuexin Yu (733842) |
| author2 | Jing Hu (41899) Yuhao Tan (15227659) Mingyao Pan (21587178) Hongyi Zhang (431841) Bo Li (112195) |
| author2_role | author author author author author |
| author_facet | Xuexin Yu (733842) Jing Hu (41899) Yuhao Tan (15227659) Mingyao Pan (21587178) Hongyi Zhang (431841) Bo Li (112195) |
| author_role | author |
| dc.creator.none.fl_str_mv | Xuexin Yu (733842) Jing Hu (41899) Yuhao Tan (15227659) Mingyao Pan (21587178) Hongyi Zhang (431841) Bo Li (112195) |
| dc.date.none.fl_str_mv | 2025-06-23T17:28:54Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1013090.g004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/MitoTracer_identified_essential_primary_BRAF_inhibitor-resistant_genes_/29384208 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetics Molecular Biology Evolutionary Biology Cancer Infectious Diseases Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> mitochondrial natural genetic markers mutated cancer cells inferred evolutionary lineage existing methods measured informative mitochondrial mutations benchmarked mitotracer using based lineage tracing informative mt mutations mutations serve work provided valuable tool superior performance mt mutation mitotracer facilitates inhibitor resistance high sensitivity genes related fundamental challenge |
| dc.title.none.fl_str_mv | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A)The reconstructed lineage was visualized by heatmap from MitoTracer. All these cells were clustered into two major clusters labeled “Cluster_1” and “Cluster_2”. Cells were labeled according to their original BRAF inhibitor resistance status, “Resistant” and “Parental”. We also labeled the primary resistant cells predicted by MitoTracer with “Resistant Cells”. (B) Graphic description of positive selection for primary resistant-related MT mutation, MT_16389_G-A. (C) Gene ontology biological process enrichment results of 674 differentially expressed genes. (D) GSEA enrichment results of 674 differentially expressed genes. (E) The overall expression level across resistant and MT_16389_G-A status. We defined the group “MT0” which presented the cells with MT_16389_G-A mutation, and MT1 indicated the cells without MT_16389_G-A mutation. (F-G) the expression level of PSMB3, SNRPD2, and UBL5 across resistant and MT_16389_G-A status. The definition of the group was the same as (E). ***P < 0.0001 and **** P < 0.00001.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_aed3ca9fe170ed09702000fc92eeee97 |
| identifier_str_mv | 10.1371/journal.pcbi.1013090.g004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29384208 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | MitoTracer identified essential primary BRAF inhibitor-resistant genes.Xuexin Yu (733842)Jing Hu (41899)Yuhao Tan (15227659)Mingyao Pan (21587178)Hongyi Zhang (431841)Bo Li (112195)GeneticsMolecular BiologyEvolutionary BiologyCancerInfectious DiseasesPlant BiologyBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedxlink "> mitochondrialnatural genetic markersmutated cancer cellsinferred evolutionary lineageexisting methods measuredinformative mitochondrial mutationsbenchmarked mitotracer usingbased lineage tracinginformative mt mutationsmutations servework providedvaluable toolsuperior performancemt mutationmitotracer facilitatesinhibitor resistancehigh sensitivitygenes relatedfundamental challenge<p>(A)The reconstructed lineage was visualized by heatmap from MitoTracer. All these cells were clustered into two major clusters labeled “Cluster_1” and “Cluster_2”. Cells were labeled according to their original BRAF inhibitor resistance status, “Resistant” and “Parental”. We also labeled the primary resistant cells predicted by MitoTracer with “Resistant Cells”. (B) Graphic description of positive selection for primary resistant-related MT mutation, MT_16389_G-A. (C) Gene ontology biological process enrichment results of 674 differentially expressed genes. (D) GSEA enrichment results of 674 differentially expressed genes. (E) The overall expression level across resistant and MT_16389_G-A status. We defined the group “MT0” which presented the cells with MT_16389_G-A mutation, and MT1 indicated the cells without MT_16389_G-A mutation. (F-G) the expression level of PSMB3, SNRPD2, and UBL5 across resistant and MT_16389_G-A status. The definition of the group was the same as (E). ***P < 0.0001 and **** P < 0.00001.</p>2025-06-23T17:28:54ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1013090.g004https://figshare.com/articles/figure/MitoTracer_identified_essential_primary_BRAF_inhibitor-resistant_genes_/29384208CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/293842082025-06-23T17:28:54Z |
| spellingShingle | MitoTracer identified essential primary BRAF inhibitor-resistant genes. Xuexin Yu (733842) Genetics Molecular Biology Evolutionary Biology Cancer Infectious Diseases Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> mitochondrial natural genetic markers mutated cancer cells inferred evolutionary lineage existing methods measured informative mitochondrial mutations benchmarked mitotracer using based lineage tracing informative mt mutations mutations serve work provided valuable tool superior performance mt mutation mitotracer facilitates inhibitor resistance high sensitivity genes related fundamental challenge |
| status_str | publishedVersion |
| title | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| title_full | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| title_fullStr | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| title_full_unstemmed | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| title_short | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| title_sort | MitoTracer identified essential primary BRAF inhibitor-resistant genes. |
| topic | Genetics Molecular Biology Evolutionary Biology Cancer Infectious Diseases Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> mitochondrial natural genetic markers mutated cancer cells inferred evolutionary lineage existing methods measured informative mitochondrial mutations benchmarked mitotracer using based lineage tracing informative mt mutations mutations serve work provided valuable tool superior performance mt mutation mitotracer facilitates inhibitor resistance high sensitivity genes related fundamental challenge |