Induction of caspase-3 activity in HT-29 and HCT116 cells treated with ABT-NPs, VOR-NPs, or DLNPs. (A) HT-29 and (B) HCT116 cells were treated with BNPs, 2 µM ABT-NPs, 1 µM VOR-NPs, or equivalent concentration of DLNPs for 72 hours Caspase-3 activity was quantified using a colorimetric caspase-3 assay and expressed as fold change relative to BNPs controls.

Induction of caspase-3 activity in HT-29 and HCT116 cells treated with ABT-NPs, VOR-NPs, or DLNPs. (A) HT-29 and (B) HCT116 cells were treated with BNPs, 2 µM ABT-NPs, 1 µM VOR-NPs, or equivalent concentration of DLNPs for 72 hours Caspase-3 activity was quantified using a colorimetric caspase-3 assay and expressed as fold change relative to BNPs controls.

<p>Data are shown as mean ± SD (n = 3). Statistical significance was determined using one-way ANOVA with Tukey’s post hoc test. <b>*</b> <i><i>p</i></i> < 0.05, <b>**</b> <i><i>p</i></i> < 0.01, <b>***</b>...

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Bibliographic Details
Main Author:	Dina Raed Abu Alsamen (22410916) (author)
Other Authors:	Zainab Zaki Zakaraya (20448340) (author), Anas Abed (17940463) (author), Alhareth A. Alsa’d (17940466) (author), Maysoon Raed Alnajdawi (22410919) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Pharmacology Biotechnology Developmental Biology Cancer Virology Space Science Chemical Sciences not elsewhere classified tested molar ratios holds great potential cytotoxicity studies revealed control drug release bioavailability present challenges 49 &# 181 32 &# 181 04 &# 181 study initially focused maintained good stability histone deacetylase inhibitor 3 &# 8201 lowest ci values colorectal cancer cells ci values consistently 2 molar ratio 2 &# 8201 div >< p 6 &# 8201 1 molar ratio vorinostat exhibiting ic synergistic anticancer effects 199 displayed ic 5 %, respectively nps ), vorinostat 2 inhibitor synergistic effects study aimed nps ), enhance stability 3 activity values close proliferative effects hct116 cells apoptotic cells antiproliferative effects unencapsulated counterparts talalay method significantly increased pronounced synergy proliferative effect proliferative activity poor solubility nanoprecipitation method increasing caspase glycolic acid formulated using flow cytometry encapsulation efficiencies effective treatment
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