Associations between antibody Fc features and broad HIV-1 neutralization activity.

<p>(A) Spearman correlation analysis between the antibody features analyzed in this study at 6 months post-seroconversion (SC) and geometric mean (geomean) half-maximal infective dilution (ID<sub>50</sub>) pseudovirus neutralization titers at 3 years post-SC (n = 166). Antibody fea...

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Bibliographic Details
Main Author:	Marloes Grobben (12465894) (author)
Other Authors:	Margreet Bakker (255262) (author), Angela I. Schriek (12548386) (author), Liesbeth J.J. Levels (20417064) (author), Jeffrey C. Umotoy (1734142) (author), Khadija Tejjani (12557846) (author), Mariëlle J. van Breemen (5090225) (author), Ryan N. Lin (20417067) (author), Steven W. de Taeye (8801435) (author), Gabriel Ozorowski (711509) (author), Neeltje A. Kootstra (8157396) (author), Andrew B. Ward (7832180) (author), Stephen J. Kent (90625) (author), P. Mark Hogarth (5644580) (author), Bruce D. Wines (5644577) (author), Rogier W. Sanders (8078546) (author), Amy W. Chung (7487030) (author), Marit J. van Gils (9323428) (author)
Published:	2024
Subjects:	Medicine Neuroscience Biotechnology Immunology Cancer Statistics Infectious Diseases Virology Computational Biology Chemical Sciences not elsewhere classified therefore alternative therapeutics potential beneficial effects fc &# 947 delayed disease progression approximately 6 months several antibody features antibody fc features xlink "> hiv 20 different hiv potent antibody neutralization polyfunctional antibody response studied antibody polyfunctionality antibody features associated 1 infection leads 3 years post 3 years new antibody 1 infection polyfunctional antibodies untreated hiv high hiv untreated individuals strong correlations strong association specific profile serum samples protective vaccine properties underlying poorly understood neutralization breadth low igg2 long treatment igg4 levels correlated positively based therapy also compared also associated
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Associations between antibody Fc features and broad HIV-1 neutralization activity.

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