Figure 5 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

Figure 5 from Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

<p>Intracellular pH shift of FRCs contributes to mitochondrial changes and the observed signature. <b>A,</b> Metabolic analysis of mitochondrial function in the computational model. Shown is OCR for mitochondria exposed to LA versus control. <b>B,</b> Quantification of...

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Main Author: Angela Riedel (15130557) (author)
Other Authors: Moutaz Helal (15130560) (author), Luisa Pedro (15130563) (author), Jonathan J. Swietlik (15130566) (author), David Shorthouse (2733004) (author), Werner Schmitz (15130569) (author), Lisa Haas (15130572) (author), Timothy Young (15130575) (author), Ana S.H. da Costa (15130578) (author), Sarah Davidson (8254992) (author), Pranjali Bhandare (13789834) (author), Elmar Wolf (14952454) (author), Benjamin A. Hall (199856) (author), Christian Frezza (15130581) (author), Thordur Oskarsson (2313193) (author), Jacqueline D. Shields (14889899) (author)
Published: 2025
Subjects:
Cancer
Tumor Biology
Molecular and Cellular Biology
Immuno-oncology
Immunology
Immune responses to cancer
Metabolism
Mitochondrial function
Progression, Invasion & Metastasis
Metastasis
Tumor Microenvironment
Tumor-stromal cell interactions
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