Comparison of the ligand binding pocket of GPR1 (marine blue) and CMKLR1 (cyan).

Comparison of the ligand binding pocket of GPR1 (marine blue) and CMKLR1 (cyan).

<p><b>(A)</b> Sphere representation of C9 bound to GPR1 is shown in orange, and the C9 bound to CMKLR1 is shown in magenta. W<sup>6.48</sup> “toggle switch” is highlighted with stick representation. <b>(B)</b> Key interaction residues of the binding pockets...

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Bibliographic Details
Main Author:	Aijun Liu (5579711) (author)
Other Authors:	Yezhou Liu (6718037) (author), Geng Chen (194556) (author), Wenping Lyu (3773128) (author), Fang Ye (112854) (author), Junlin Wang (4029803) (author), Qiwen Liao (3905665) (author), Lizhe Zhu (383604) (author), Yang Du (506908) (author), Richard D. Ye (2353900) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Evolutionary Biology Inorganic Chemistry Infectious Diseases Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified molecular dynamics simulations site &# 8221 lid &# 8221 coupled receptor 1 xlink "> chemerin like receptor 1 structural model explains length chemerin uses 3 g protein coupled gpr1 bound tm binding pocket c chemokine receptor length chemerin g protein binding pocket coupled receptors &# 8220 like 2 chemerin binds yfpgqfafs ). terminal nonapeptide terminal core resolution cryo present high including chemokine gpr1 signaling gpr1 ), functional assays energetically expensive em structures combining results chemotactic activity ccrl2 ). activating peptide
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