Comparison of the ligand binding pocket of GPR1 (marine blue) and CMKLR1 (cyan).

Comparison of the ligand binding pocket of GPR1 (marine blue) and CMKLR1 (cyan).

<p><b>(A)</b> Sphere representation of C9 bound to GPR1 is shown in orange, and the C9 bound to CMKLR1 is shown in magenta. W<sup>6.48</sup> “toggle switch” is highlighted with stick representation. <b>(B)</b> Key interaction residues of the binding pockets...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Aijun Liu (5579711) (author)
مؤلفون آخرون: Yezhou Liu (6718037) (author), Geng Chen (194556) (author), Wenping Lyu (3773128) (author), Fang Ye (112854) (author), Junlin Wang (4029803) (author), Qiwen Liao (3905665) (author), Lizhe Zhu (383604) (author), Yang Du (506908) (author), Richard D. Ye (2353900) (author)
منشور في: 2024
الموضوعات:
Biophysics
Biochemistry
Cell Biology
Molecular Biology
Evolutionary Biology
Inorganic Chemistry
Infectious Diseases
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
molecular dynamics simulations
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lid &# 8221
coupled receptor 1
xlink "> chemerin
like receptor 1
structural model explains
length chemerin uses
3 g protein
coupled gpr1 bound
tm binding pocket
c chemokine receptor
length chemerin
g protein
binding pocket
coupled receptors
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like 2
chemerin binds
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terminal nonapeptide
terminal core
resolution cryo
present high
including chemokine
gpr1 signaling
gpr1 ),
functional assays
energetically expensive
em structures
combining results
chemotactic activity
ccrl2 ).
activating peptide
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الوصف
الملخص:<p><b>(A)</b> Sphere representation of C9 bound to GPR1 is shown in orange, and the C9 bound to CMKLR1 is shown in magenta. W<sup>6.48</sup> “toggle switch” is highlighted with stick representation. <b>(B)</b> Key interaction residues of the binding pockets of GPR1 and CMKLR1 are shown in licorice representation. The ligands respectively bound to the 2 receptors are shown as ribbon. The distance of the ligands is calculated and shown as a centroid distance of 1.2 Å.</p> <p>(TIFF)</p>

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