Material parameters used in the in silico organoid FEM model obtained by manual optimization based on both relevant global organoid morphology simulations and the literature.

Material parameters used in the in silico organoid FEM model obtained by manual optimization based on both relevant global organoid morphology simulations and the literature.

<p>Material parameters used in the in silico organoid FEM model obtained by manual optimization based on both relevant global organoid morphology simulations and the literature.</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Julien Laussu (3554030) (author)
مؤلفون آخرون:	Deborah Michel (5747045) (author), Léa Magne (20543036) (author), Stephane Segonds (20543039) (author), Steven Marguet (20543042) (author), Dimitri Hamel (20543045) (author), Muriel Quaranta-Nicaise (17445687) (author), Frederick Barreau (3808855) (author), Emmanuel Mas (369164) (author), Vincent Velay (20543048) (author), Florian Bugarin (20543051) (author), Audrey Ferrand (8931287) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Genetics Molecular Biology Physiology Biotechnology Developmental Biology Inorganic Chemistry Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> understanding tyssue library ), level strain due freely available tools finite element method abaqus fem solver mechanical cues involved mechanical aspects involved human colon organoid finite element analysis enables better assessment computational approaches enabling organoids &# 8217 human colon organoids 3d tissue organization mechanical stresses experienced fem model provides depicting cell shape vertex model achieved tissue architecture establishment fem approaches mechanical analysis mechanical parameters organoid morphology imposed stresses better fit vertex model synthetic model biological model tissue deformation tissue architecture various stages multiple levels mature morphology improves modeling geometric parameters extracted architectural external solicitation combining geometrical combined vertex challenge requires cell behavior active contraction 120 hours
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