Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target

Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target

Cystic fibrosis (CF) pharmacological correctors improve the cystic fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Several side effects of these correctors and adverse drug interactions have been reported, emphasizing the need to understand off-targets. We synth...

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Bibliographic Details
Main Author: Minsoo Kim (171626) (author)
Other Authors: Kwangho Kim (1343724) (author), Jesun Lee (21577553) (author), Lea A. Barny (14555843) (author), Toya D. Scaggs (6824642) (author), Ian M. Romaine (335211) (author), KyuOk Jeon (19333198) (author), Simona G. Codreanu (2195107) (author), Stacy D. Sherrod (1325025) (author), John A. McLean (696579) (author), Anjaparavanda P. Naren (21577556) (author), Gary A. Sulikowski (214879) (author), Lars Plate (1265706) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Neuroscience
Pharmacology
Immunology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
several side effects
psychological symptoms observed
potential inhibitory activity
data show dysregulation
amino acid metabolism
also characterized changes
adverse drug interactions
uncharacterized putative oxidoreductase
target may explain
target cystic fibrosis
cells overexpressing sccpdh
pharmacological correctors improve
identified saccharopine dehydrogenase
functionalized photoaffinity ligand
445 identifies sccpdh
photoaffinity ligand
like oxidoreductase
sccpdh ),
synthesized vu439
protein trafficking
metabolomic profiles
mass spectrometry
linked proteins
identify cross
chemoproteomics analysis
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