HAstV-1 internalization and uncoating are delayed in FcRn-KO Caco-2 cells.

<p>(A) HAstV-1 at an MOI of 0.02 was added to WT or FcRn-KO Caco-2 cells for 1 h at 4ºC. The cells were switched to 37ºC and incubated for the indicated times to allow virus internalization. To remove the virus adsorbed to the cell surface that had not been internalized at different time point...

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Bibliographic Details
Main Author:	Catalina Aguilera-Flores (21743843) (author)
Other Authors:	María del Pilar Valencia-Morales (21743846) (author), Tomás López (3465071) (author), Joaquín Moreno-Contreras (11999401) (author), Adam Lentz (21743849) (author), Marco A. Espinoza (11999404) (author), Rebecca M. DuBois (145825) (author), Susana López (606291) (author), Carlos F. Arias (8144190) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Molecular Biology Immunology Cancer Mental Health Infectious Diseases Virology Biological Sciences not elsewhere classified offering relevant implications neutralizing monoclonal antibodies dipeptidyl peptidase iv amino acid residues two amino acids infectious virus assays classical human astroviruses 2 cells compared facilitating viral internalization hastv previously mapped 1 genome uncoating ko ), dpp4 mabs targeting hastv classical hastv wt cells vaccines targeting two proteins rna genome attachment assays viral gastroenteritis hastv infection divergent hastv spatially proximal results showed recent studies ray crystallography precise roles immunocompromised individuals global cause functional domain epitope footprint entry factor dpp4 serves dpp4 double delayed threefold clinical significance cellular receptors cell infection binding sites antiviral therapies 8 variants
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HAstV-1 internalization and uncoating are delayed in FcRn-KO Caco-2 cells.

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