Kidney Multiome-based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants (Datasets)

Kidney Multiome-based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants (Datasets)

<p dir="ltr">Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-spe...

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Main Author: Hongbo Liu (11286261) (author)
Other Authors: Amin Abedini (2809522) (author), Eunji Ha (4739670) (author), Ziyuan Ma (5783051) (author), Xin Sheng (219717) (author), Chengxiang Qiu (240673) (author), Bernhard Dumoulin (15235922) (author), Tamas Aranyi (3577955) (author), Shen Li (432920) (author), Nicole Dittrich Hosni (11106310) (author), Hua-Chang Chen (17827539) (author), Ran Tao (81449) (author), Der-Cherng Tarng (114877) (author), Feng-Jen Hsieh (4738317) (author), Shih‐Ann Chen (12837695) (author), Shun-Fa Yang (155103) (author), Mei-Yueh Lee (508355) (author), Kwok, Pui-Yan (16943292) (author), Jer-Yuarn Wu (92059) (author), Chien-Hsiun Chen (28863) (author), Atlas Khan (6161267) (author), Nita A. Limdi (18130416) (author), Wei-Qi Wei (4232797) (author), Theresa L. Walunas (5063474) (author), Elizabeth W. Karlson (11935646) (author), Eimear E. Kenny (6830078) (author), Yuan Luo (10799) (author), Leah Kottyan (12971751) (author), John J. Connolly (12570439) (author), Gail P. Jarvik (8636064) (author), Chunhua Weng (3387569) (author), Ning Shang (11598436) (author), Joanne B. Cole (3080733) (author), Josep M. Mercader (7439093) (author), Ravi Mandla (15992561) (author), Timothy D. Majarian (6269588) (author), Jose C. Florez (114792) (author), Mary Haas (3968453) (author), Luca A. Lotta (397633) (author), Regeneron Genetics Center (13904802) (author), GHS-RGC DiscovEHR Collaboration (14898542) (author), Theodore G. Drivas (19445598) (author), Penn Medicine Biobank (17800367) (author), Ha My T. Vy (10031953) (author), Girish N. Nadkarni (3044592) (author), Laura K. Wiley (20609335) (author), Melissa P. Wilson (9581031) (author), Christopher R. Gignoux (7852499) (author), Humaira Rasheed (2190091) (author), Laurent F. Thomas (11849357) (author), Bjørn Olav Åsvold (9767022) (author), Ben M. Brumpton (8796050) (author), Stein I Hallan (8335629) (author), Kristian Hveem (189996) (author), Jie Zheng (5065178) (author), Jacklyn N. Hellwege (2889977) (author), Matthew Zawistowski (6836705) (author), Sebastian Zöllner (140100) (author), Nora Franceschini (91434) (author), Hailong Hu (581221) (author), Jianfu Zhou (13844328) (author), Krzysztof Kiryluk (156863) (author), Marylyn D. Ritchie (201209) (author), Matthew Palmer (2839712) (author), Todd L. Edwards (153243) (author), Benjamin F. Voight (145685) (author), Adriana M. Hung (613817) (author), Katalin Susztak (11286335) (author)
Published: 2025
Subjects:
Epigenetics (incl. genome methylation and epigenomics)
Genomics
Kidney function
GWAS
Allele-specific expression
Allle-specific accessibility
Single cell multiome
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