Hydroxyurea induces NPC clustering and ER expansion.

(A) Left: Confocal microscopy images of wild-type cells expressing GFP-tagged nucleoporin Cut11 in untreated conditions (left) and after 4 hours in 15 mM HU (center) or 75 mM HU (right). Asterisks marks cells in which NPC clustering is observed. Center:...

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Bibliographic Details
Main Author:	Ana Sánchez-Molina (22648139) (author)
Other Authors:	Manuel Bernal (179798) (author), Joel D. Posligua-García (22648142) (author), Antonio J. Pérez-Pulido (9754780) (author), Laura de Cubas (13037335) (author), Elena Hidalgo (51458) (author), M.-Henar Valdivieso (142037) (author), Silvia Salas-Pino (179803) (author), Rafael R. Daga (22648148) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified schizosaccharomyces pombe </ proper redox environment protein folding within dependent protein folding nuclear pore complexes disulfide bond formation dia treatments resulted triggers er expansion oxidative stress response er expansion results hu impacts redox div >< p antineoplastic agent hydroxyurea disulfide stress correct folding reducing agent nuclear envelope dia ), thiol stress striking phenotype ssa1 chaperones specific region specific inducer secretory pathway rapidly reversed proteins entering precise mechanisms misfolded proteins lumen provides hydroxyurea induces fully elucidated forming membranes endoplasmic reticulum data show
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Hydroxyurea induces NPC clustering and ER expansion.

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