Characterization of tsAb thermal stability.

Characterization of tsAb thermal stability.

<p>nDSF profiles were obtained from four different clones within two different mispairing groups. <b>(A)</b> clone A and <b>(B)</b> clone D corresponding to lower mispairing and clone F <b>(C)</b> and clone H <b>(D)</b> to higher mispairing clone...

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Bibliographic Details
Main Author: Catarina Melo (22656029) (author)
Other Authors: Sofia B. Carvalho (12009237) (author), Maria J. Sebastião (22656032) (author), Ricardo A. Gomes (198735) (author), Pedro M. F. Sousa (12969465) (author), Patrícia Gomes-Alves (5898956) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Immunology
Inorganic Chemistry
Chemical Sciences not elsewhere classified
surface plasmon resonance
revealing distinct profiles
performance liquid chromatography
lower mispairing levels
implemented mass spectrometry
enhanced therapeutic potential
differential scanning fluorometry
also clarified samples
three different antigens
different mispairing levels
binary interactions established
mispairing analytical toolbox
msab mispairing profiles
stage screenings enabling
stage screenings
different epitopes
stage screening
analytical tools
analytical characterization
work allowed
thus increasing
significant burden
results showed
reducing costs
overall timeline
multispecific antibodies
methods established
intracellular assembly
downstream processing
clones producing
biophysical tools
antibody functionality
analysis time
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