Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery

Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery

The clinical use of small interfering RNA (siRNA) and antisense oligonucleotides often requires invasive routes of administration, including intrathecal or intraocular injection. Additionally, these treatments often necessitate repeated injections. While nanoparticle formulation and chemical modific...

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Bibliographic Details
Main Author: Yan Liu (25061) (author)
Other Authors: Yang Wang (5921) (author), Rajesh A. Kulkarni (6824630) (author), Lindsay Anne Wegiel (20460398) (author), Byungkook Lee (35660) (author), Sean K. Bedingfield (6243449) (author), David Weitz (263020) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Genetics
Molecular Biology
Pharmacology
Sociology
Cancer
Chemical Sciences not elsewhere classified
varying molecular weights
small interfering rna
defined size distribution
>- glycolic acid
vivo release profiles
vitro release test
various injection routes
high loading capacity
controllable sirna delivery
conjugated sirna locally
8900 μg sirna
microcapsules effectively shield
intraocular injection
high toxicity
release formulations
using microfluidics
syringable microcapsules
side effects
shell thickness
selected based
released constantly
needles ranging
nearly 100
nanoparticle formulation
microcapsules show
maximum exposure
lactic -<
injected subcutaneously
including intrathecal
gauge sizes
findings demonstrate
co </
clinical use
chemical modifications
challenges persist
bolus injections
based method
average diameter
acute phase
32 g
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