Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery

The clinical use of small interfering RNA (siRNA) and antisense oligonucleotides often requires invasive routes of administration, including intrathecal or intraocular injection. Additionally, these treatments often necessitate repeated injections. While nanoparticle formulation and chemical modific...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yan Liu (25061) (author)
مؤلفون آخرون:	Yang Wang (5921) (author), Rajesh A. Kulkarni (6824630) (author), Lindsay Anne Wegiel (20460398) (author), Byungkook Lee (35660) (author), Sean K. Bedingfield (6243449) (author), David Weitz (263020) (author)
منشور في:	2024
الموضوعات:	Biophysics Biochemistry Genetics Molecular Biology Pharmacology Sociology Cancer Chemical Sciences not elsewhere classified varying molecular weights small interfering rna defined size distribution >- glycolic acid vivo release profiles vitro release test various injection routes high loading capacity controllable sirna delivery conjugated sirna locally 8900 μg sirna microcapsules effectively shield intraocular injection high toxicity release formulations using microfluidics syringable microcapsules side effects shell thickness selected based released constantly needles ranging nearly 100 nanoparticle formulation microcapsules show maximum exposure lactic -< injected subcutaneously including intrathecal gauge sizes findings demonstrate co </ clinical use chemical modifications challenges persist bolus injections based method average diameter acute phase 32 g
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Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery

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