Additional file 4 of Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations

Supplementary Material 4

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Bibliographic Details
Main Author:	Hongyu Zhu (4722834) (author)
Other Authors:	Shihua Liu (10493014) (author), Jiaqi Qiu (6262187) (author), Ankang Hu (12073505) (author), Wanyi Zhou (13228411) (author), Jian Wang (5901) (author), Weihang Gu (20792802) (author), Yinuo Zhu (14320333) (author), Hao Zha (9337724) (author), Rong Xiang (164808) (author), Junli Li (193664) (author), Rui Qiu (2657167) (author), Chong Zhao (495389) (author), Peng Huang (105814) (author), Xiaowu Deng (780577) (author)
Published:	2025
Subjects:	Biophysics Medicine Cell Biology Physiology Sociology Cancer Biological Sciences not elsewhere classified radiation shows promise optimizing radiotherapy strategies method female c57bl6 large field sizes instantaneous dose rate dose rate effects normal tissue toxicities intestinal tissues revealed mean dose rate reducing radiation damages perform transcriptome sequencing high dose rate 10 gy tbi lh irradiations compared lh irradiation compared reduced mice mortality lh mode ), transcriptome sequencing reducing mortality intestinal tissue lh mode lh irradiations significantly reduced dna damages mode ). low mean high mean body irradiations various factors study aimed potential benefits pivotal role murine total findings underscore evaluate survival eradicating tumors dna damage comparative study cell apoptosis body irradiation biological responses biological outcomes 30 days 3 h
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