HSF2 regulates ORF50 expression in an RTA independent manner.

HSF2 regulates ORF50 expression in an RTA independent manner.

<p><b>(A–D)</b> Luciferase reporter assay in HEK293FT cells co transfected in triplicate with a plasmid harboring the luciferase reporter gene downstream of a control basic promoter (control) or the indicated viral promoters (A, C, D) or viral origins of replication <b>(B)<...

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Bibliographic Details
Main Author: Lorenza Cutrone (21144285) (author)
Other Authors: Hedvig Djupenström (21144288) (author), Jasmin Peltonen (21144291) (author), Elena Martinez Klimova (21144294) (author), Simona Corso (50653) (author), Silvia Giordano (50663) (author), Lea Sistonen (21144297) (author), Silvia Gramolelli (305486) (author)
Published: 2025
Subjects:
Medicine
Microbiology
Cell Biology
Genetics
Molecular Biology
Immunology
Developmental Biology
Cancer
Mental Health
Hematology
Infectious Diseases
Biological Sciences not elsewhere classified
transcriptionally permissive state
repressive histone marks
offer new insights
default infection program
complex process unresolved
hsf2 significantly decreases
findings identify hsf2
endogenous hsf2 binds
ectopic hsf2 enhances
detected hsf2 binding
transcription factor involved
host factors governing
poised gene promoters
poised chromatin features
herpesvirus gene expression
ebv bzlf1 genes
transcription factors
hsf2 overexpression
hsf2 occupancy
hsf2 ),
sarcoma herpesvirus
lytic genes
ebv bzlf1
yet complete
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wide range
stress responses
results demonstrate
proteasomal degradation
lytic phase
lytic cells
leaving much
decreased levels
causally associated
barr virus
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