H655Y sensitizes CoV replicon viral particle neutralization by S2 stem-helix antibodies and HR2 peptides.

<p><b>A.</b> Schematic of SARS-CoV-2 replicon virion generation. VSVG-pseudotyped virions were initially recovered from supernatant of HEK293T cells transfected with Bacmid ΔS Luc-GFP and VSVG expression plasmid. This supernatant then went through three rounds of enrichment in VSVG...

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Bibliographic Details
Main Author:	Enya Qing (20371303) (author)
Other Authors:	Julisa Salgado (20371306) (author), Alexandria Wilcox (20371309) (author), Tom Gallagher (4288378) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Molecular Biology Neuroscience Evolutionary Biology Immunology Cancer Infectious Diseases Virology Computational Biology specific h655y change peripheral &# 8220 essential final step membrane &# 8220 stage fusion dynamics cell entry dynamics s2 &# 8221 s1 &# 8221 novel neutralization mechanism endemic infection patterns domains altered late directed membrane fusion cell membrane fusion cell entry membrane fusion targeting fusion fusion kinetics early fusion s1 stabilized results exemplify protein conformation optimize transmission latter aspect latest stages inhibitory peptides increase sensitivity human cells findings demonstrate continuous presence antibody neutralization activating steps
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H655Y sensitizes CoV replicon viral particle neutralization by S2 stem-helix antibodies and HR2 peptides.

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