SAMD9L restricts replication of multiple mosquito-borne flaviviruses.

<p><b>(A)</b> HEK293T cells were transduced with individual lentiviral vectors encoding different ISGs for 72 h, followed by infection with WNV or USUV at a MOI of 1 for 48 h. Infection and transduction efficiencies were assessed by flow cytometry. Infection rates are shown as perc...

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Bibliographic Details
Main Author:	Marion Cannac (21714117) (author)
Other Authors:	Jim Zoladek (9262689) (author), Inès Bribes (13822942) (author), Mathis Fresneau--Resende (22806406) (author), Alexandre Legrand (397444) (author), Rémi Demeure (22806409) (author), Eva Zusinaite (7461902) (author), Andres Merits (191446) (author), Lucie Etienne (450881) (author), Sébastien Nisole (88157) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Molecular Biology Immunology Cancer Science Policy Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified spectrum restriction factor proteins restrict poxvirus like ribonuclease domain innate immune response including microglial cells human myeloid cells known antiviral repertoire important antiviral effectors efficiently suppressed replication primary target cells innate immune activation key antiviral isg mediated antiviral activity xlink "> interferon identify human samd9l flaviviral rna outside inhibit flavivirus replication antiviral activity flaviviral rna reovirus replication primary macrophages key component activation may inhibitory activity activity depends flavivirus infection usuv ). stimulated genes since samd9l recently emerged previously implicated pivotal role paralog samd9l inhibit hiv identifying samd9l findings broaden exogenous expression evolved mechanisms essential role denv ), cellular defenses
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SAMD9L restricts replication of multiple mosquito-borne flaviviruses.

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