Inter-individual variability in total rDNA CN, unmethylated rDNA CN, methylated rDNA CN, contributes to similarly wide variability in percent of methylated rDNA copies.

A,B rDNA tCN range from 60.49 to 263.7 copies per haploid (equivalent to between121 and 527.4 copies per cell). rDNA uCN range from 47.39 to 180.9 copies per haploid. rDNA mCN range from 5.58 to 154.8 copies per haploid. The methylation percentage was f...

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Bibliographic Details
Main Author:	Stephen Flint Smith (22614954) (author)
Other Authors:	Bernardo Lemos (223826) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Cancer Plant Biology least four cpgs found significant correlations bisulfite pcr targeting 20 ng dna 15 ng dna rdna transcriptional activity single copy gene observed wide variation unmethylated rdna cn total rdna copies total rdna cn detecting rdna cn humans &# 160 rdna methylation variability rdna methylation status methylated rdna copies methylated rdna cn rdna copies rdna cn rdna methylation methylated copies 3 ng natural variation copy number within species varies widely simultaneous quantification simultaneous detection scalable approach practical range partially regulated offering insight new tool modified methyl method provides linear range healthy donors greater number
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Inter-individual variability in total rDNA CN, unmethylated rDNA CN, methylated rDNA CN, contributes to similarly wide variability in percent of methylated rDNA copies.

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