CPAF mediates chlamydial-induced ferroptosis through proteolytic degradation of SLC7A11 in host cells.

CPAF mediates chlamydial-induced ferroptosis through proteolytic degradation of SLC7A11 in host cells.

<p>(<b>A</b>) The mRNA expression of SLC7A11 and GPx4 in <i>Chlamydia trachomatis</i> serovar D (MOI 10)-infected cells was measured by SYBR Green qPCR at 72 h.p.i., compared to mock-infected cells. Statistical analysis was performed using Student’s t-test. Data are pre...

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Main Author: Wentao Chen (626428) (author)
Other Authors: Xin Su (338394) (author), Yuying Pan (14800243) (author), Han Zhou (109068) (author), Yidan Gao (14620035) (author), Xuemei Wang (39992) (author), Lijuan Jiang (501223) (author), Lihong Zeng (15594179) (author), Qingqing Xu (465549) (author), Xueying Yu (605947) (author), Xiaona Yin (9023591) (author), Zhanqin Feng (3721183) (author), Bao Zhang (186933) (author), Wei Zhao (14321) (author), Yaohua Xue (3150252) (author), Lingli Tang (436791) (author), Heping Zheng (538162) (author)
Published: 2025
Subjects:
Biophysics
Microbiology
Cell Biology
Immunology
Cancer
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
vitamin e reduces
trends toward attenuation
prevalent bacterial agent
low genital tract
like activity factor
host protein slc7a11
host cells plays
deficient strain fails
conserved survival strategies
sexually transmitted infections
chlamydia trachomatis ,</
cpaf ), resulting
new infections
chlamydia </
significant threat
reproductive health
process involves
orchestrated lysis
novel mechanism
lipid peroxidation
inhibiting ferroptosis
induce ferroptosis
glutathione depletion
crucial role
chlamydial protease
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