Figure 2 from Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors

Figure 2 from Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors

<p>PARPi and ATRi have synergistic cytotoxic effects in models of DSRCT with high PARP1 expression. <b>A</b> and <b>B,</b> PARP1 expression (<b>A</b>) and PARylation levels (<b>B</b>) as assessed by IHC in a cohort of 16 DSRCT samples, compared w...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Asuka Kawai-Kawachi (20493784) (author)
مؤلفون آخرون: Madison M. Lenormand (20493787) (author), Clémence Astier (20493790) (author), Noé Herbel (20493793) (author), Meritxell B. Cutrona (20493796) (author), Carine Ngo (20493799) (author), Marlène Garrido (20493802) (author), Thomas Eychenne (20493805) (author), Nicolas Dorvault (20493808) (author), Laetitia Bordelet (20493811) (author), Feifei Song (14961627) (author), Ryme Bouyakoub (20493814) (author), Anastasia Loktev (20493817) (author), Antonio Romo-Morales (20493820) (author), Clémence Henon (20493823) (author), Léo Colmet-Daage (20493826) (author), Julien Vibert (15053998) (author), Marjorie Drac (20493829) (author), Rachel Brough (14961636) (author), Etienne Schwob (20493832) (author), Oliviano Martella (20493835) (author), Guillaume Pinna (20493838) (author), Janet M. Shipley (15091942) (author), Sibylle Mittnacht (20493841) (author), Astrid Zimmermann (14961639) (author), Aditi Gulati (15051605) (author), Olivier Mir (15039002) (author), Axel Le Cesne (20493844) (author), Matthieu Faron (20493847) (author), Charles Honoré (20493850) (author), Christopher J. Lord (14952616) (author), Roman M. Chabanon (14952562) (author), Sophie Postel-Vinay (14946771) (author)
منشور في: 2025
الموضوعات:
Cancer
Molecular and Cellular Biology
Therapeutic Research and Development
Dna Damage And Repair
Genomic instability
Drug Mechanisms
Modulation of DNA repair
Drug Targets
Sarcomas
Soft-tissue sarcoma
Small Molecule Agents
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