Construction and verification of calcineurin gene deletion mutants and complemented strains in C. auris.

(A-C) Schematic representation of the homologous recombination strategies used to delete CNA1, CNB1, and both genes (left panels). Southern blot analyses confirm the successful deletion of the target genes (right panels). (D, E) Verification of the cons...

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Главный автор:	Hyunjin Cha (21800133) (author)
Другие авторы:	Doyeon Won (843415) (author), Seun Kang (17118302) (author), Eui-Seong Kim (18512295) (author), Kyung-Ah Lee (251243) (author), Won-Jae Lee (610790) (author), Kyung-Tae Lee (1420105) (author), Yong-Sun Bahn (210099) (author)
Опубликовано:	2025
Предметы:	Medicine Microbiology Cell Biology Genetics Pharmacology Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified systemic infection model remain poorly understood high mortality rates downstream transcription factor perform divergent roles dependent protein phosphatase complex regulatory mechanisms regulating extreme thermotolerance disrupts extreme thermotolerance increased azole susceptibility crz1 appeared dispensable antifungal drug resistance candida auris </ increased susceptibility antifungal resistance auris </ regulatory subunit opposing roles dependent manner multidrug resistance drosophila </ crz1 </ wall integrity study investigates membrane integrity fungal species fungal pathogens findings reveal findings highlight central role cell wall cell membrane catalytic subunit
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Construction and verification of calcineurin gene deletion mutants and complemented strains in <i>C. auris.</i>

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