Cerebellar Purkinje cell (PC)-specific amyloid precursor protein (APP) expression modulates motor function.

Cerebellar Purkinje cell (PC)-specific amyloid precursor protein (APP) expression modulates motor function.

<p><b>(A)</b> APP (red) and calbindin (green) immunofluorescence in 20-µm-thick cerebellar sagittal sections. The APP immunofluorescence in wild-type (<i>App</i><sup>+/+</sup>) or APP-null (<i>App</i><sup>−/−</sup>) mice were acquired...

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Hlavní autor: Miao-Jin Ji (22676552) (author)
Další autoři: Tong-Xuan Wu (22676555) (author), Chenhao Tian (10801643) (author), Xiang Cao (298023) (author), Ruyuan Wei (22676558) (author), Yin-Yin Yang (301866) (author), Xinran Meng (11537536) (author), Huanyao Tang (22676561) (author), Tiantao Cui (22676564) (author), Jiao Yang (623531) (author), Xin Tang (134573) (author), Chao Liu (43092) (author)
Vydáno: 2025
Témata:
Biochemistry
Cell Biology
Molecular Biology
Neuroscience
Physiology
Developmental Biology
Infectious Diseases
mediated sodium currents
deep cerebellar nucleus
aberrant firing patterns
specific app reconstitution
cerebellar motor control
app deficiency leads
electrophysiological analysis revealed
6 channel activity
motor performance
motor function
motor deficits
app selectively
purkinje cells
marked reduction
impaired locomotion
findings reveal
exogenous expression
essential role
dcn ).
conditional knockdown
behavioral deficits
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