Proposed molecular algorithm following a complexity-increasing order of techniques for the assessment of molecular alterations in PTC in a public hospital from a developing country.

<p>All PTC samples should be initially screened for pan-TRK and BRAF V600E proteins by immunohistochemistry (IHC). Positive cases for pan-TRK should be sequentially tested for NTRK3, NTRK1 and NTRK2 gene fusions, following NTRK genes fusion frequency by fluorescent in situ hybridization (FISH)...

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Bibliographic Details
Main Author:	Sandra Lorena Colli (12334315) (author)
Other Authors:	Marisa Esther Boycho (21273358) (author), Patricia Papendieck (21273361) (author), Franco Mauricio Mangone (21273364) (author), Ana Chiesa (13651773) (author), Mercedes García Lombardi (7397309) (author), Martín Medín (18930487) (author), Elena Noemí De Matteo (11221569) (author), Mario Alejandro Lorenzetti (12334327) (author), María Victoria Preciado (11221572) (author)
Published:	2025
Subjects:	Genetics Biotechnology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified results also broaden primary endocrine malignancy larger tumor size laboratory algorithm following higher initial risk future laboratory algorithm across geographic regions prevalent genetic alterations genetic alterations varies genetic alterations (< papillary thyroid carcinoma characterize molecular alterations pediatric thyroid carcinoma div >< p braf v600e snv thyroid cancer molecular diagnosis ptc alterations pediatric groups specific treatment situ hybridization selection tools sanger sequencing respectively ). prognostic tools pediatric ptc p </ ntrk genes ngs screening known oncogenes increasing order complexity provided
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Proposed molecular algorithm following a complexity-increasing order of techniques for the assessment of molecular alterations in PTC in a public hospital from a developing country.

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