Real-time measurements of cAMP in response to IBMX in control and AICAR-treated rat AVMs.

Non-treated (A) or AICAR-treated (B) rat AVMs were infected with cAMP sensor Epac2-camps adenovirus for 48h to estimate cAMP content. Following CFP excitation at 440±20nm, cAMP binding to the sensor induces a transient decrease in fluorescence resonance...

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Bibliographic Details
Main Author:	Anne Garnier (130125) (author)
Other Authors:	Jérôme Leroy (17020732) (author), Claudine Deloménie (17020735) (author), Philippe Mateo (201010) (author), Benoit Viollet (45915) (author), Vladimir Veksler (201015) (author), Mathias Mericskay (803832) (author), Renée Ventura-Clapier (130121) (author), Jérôme Piquereau (201006) (author)
Published:	2023
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Chemical Sciences not elsewhere classified thus examined whether rate limiting step may become deleterious 2 -/- mice enhancing cardiac output induced myocardial dysfunction cardiac camp signaling ampk &# 945 induced cardiac dysfunction unstimulated rat cardiomyocytes type calcium current mouse </ p experimental pressure overload dose response curve adenylyl cyclase 5 activated protein kinase significantly increased compared pharmacological ampk activation regulates ac5 expression pressure overload calcium current pharmacological activation cardiac response ampk activation significantly higher camp content xlink "> wt heart results show potent stimulus phosphodiesterase inhibitor ibmx ), heart failure energy metabolism decreased expression contractile function carboxamide riboside adrenergic system adrenergic stimulation adrenergic pathway adrenergic cascade ac5 expression ac5 ),
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Real-time measurements of cAMP in response to IBMX in control and AICAR-treated rat AVMs.

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