Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism
<p>Representative metabolite concentration maps from the central slice derived from a series of dynamic 3D <sup>2</sup>H CSI images summed over the first 30 minutes of signal acquisition following [2,3-<sup>2</sup>H<sub>2</sub>]fumarate injection into A11 (&...
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2025
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| Čoahkkáigeassu: | <p>Representative metabolite concentration maps from the central slice derived from a series of dynamic 3D <sup>2</sup>H CSI images summed over the first 30 minutes of signal acquisition following [2,3-<sup>2</sup>H<sub>2</sub>]fumarate injection into A11 (<b>B</b>, <b>C</b>, <b>E</b>, and <b>F</b>), S2 (<b>H</b>, <b>I</b>, <b>K</b>, and <b>L</b>), and U87 (<b>N</b>, <b>O</b>, <b>Q</b>, and <b>P</b>) tumor-bearing mice. The color code represents concentration (in mmol/L) derived from the ratios of the peak intensities in the malate and fumarate maps to peak intensities in an initial HDO map and corrected for the number of <sup>2</sup>H labels per molecule and for signal saturation. The locations of the tumors are indicated by dotted white lines determined from an underlying T<sub>2</sub>-weighted <sup>1</sup>H image acquired concurrently using a <sup>1</sup>H volume coil. The corresponding T<sub>2</sub>-weighted <sup>1</sup>H images were acquired separately at 9.4 T. The tumor locations are outlined with dotted black lines. T<sub>2</sub>-weighted <sup>1</sup>H images (<b>A</b>, <b>G</b>, and <b>M</b>) and the fumarate (<b>B</b>, <b>H</b>, and <b>N</b>) and malate (<b>C</b>, <b>I</b>, and <b>O</b>) concentration maps pretreatment and the corresponding T<sub>2</sub>-weighted <sup>1</sup>H images (<b>D</b>, <b>J</b>, and <b>P</b>) and the fumarate (<b>E</b>, <b>K</b>, and <b>Q</b>) and malate (<b>F</b>, <b>L</b>, and <b>R</b>) concentration maps 48 hours following the last chemoradiotherapy treatment.</p> |
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