Global Profiling of the Proteome and Acetylome in Mice with Abdominal Aortic Aneurysms

Abdominal aortic aneurysm (AAA) is a fatal vascular disease with a high rupture risk, and current treatments rely mainly on surgery. Pharmacological therapies are limited due to an incomplete understanding of disease mechanisms. This study aimed to identify potential targets for pharmacological inte...

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Bibliografiset tiedot
Päätekijä:	Luyao Zhang (1842607) (author)
Muut tekijät:	Bo Yang (104813) (author), Tao Ding (129078) (author), Yaling Zhao (402836) (author), Yehong Yang (7040654) (author), Xiaoyue Tang (6989228) (author), Yue Wu (1262184) (author), Qiaochu Wang (5600150) (author), Zhiyi Zhang (279187) (author), Chunmei Shi (1807591) (author), Rong Han (297984) (author), Xutong Zhang (12880445) (author), Jiangfeng Liu (3246087) (author), Juntao Yang (2136565) (author)
Julkaistu:	2025
Aiheet:	Biochemistry Medicine Genetics Molecular Biology Pharmacology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified thereby potentially attenuating sirtuin protein family identify potential targets high rupture risk 4581 acetylation sites 1790 acetylated proteins suppressing histone acetylation fatal vascular disease bioinformatics analyses revealed performed global proteomic mouse aaa model mouse model histone acetyltransferases global profiling disease mechanisms acetylomic analyses successfully established study proposes study aimed pharmacological therapies pharmacological intervention pathways co limited due incomplete understanding aortic tissues acetylomic alterations aaa using aaa treatment
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Global Profiling of the Proteome and Acetylome in Mice with Abdominal Aortic Aneurysms

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