Workflow of the developed simulation algorithm.

<p>A. An asynchronously cycling cell population (Gen 1) is initiated by sampling the initial conditions at random time points from a pool of single cell simulations run with growth factor stimulation (Gen 0). B. Upon the execution of each generation, detection of new cell division events (or l...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Arnab Mutsuddy (22146227) (author)
مؤلفون آخرون:	Jonah R. Huggins (13235400) (author), Aurore K. Amrit (22146230) (author), Atalanta Manuela Harley-Gasaway (22146233) (author), Cemal Erdem (11054081) (author), Evan T. Jones (22146236) (author), Olivia G. Laurine (22146239) (author), Jon C. Calhoun (22146242) (author), Marc R. Birtwistle (10825523) (author)
منشور في:	2025
الموضوعات:	Biophysics Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tracks simulated division strong growth inhibition slowly dividing cells mother cells prior measure cumulative division four targeted anti erk pathway activity better understanding determinants receptor inhibitor response egfr inhibitor ). 3k inhibitor ), mechanistic computational models xlink "> data cell viability assays cell cycle may simulations show subpopulations rapidly dividing phenotype drug treatment impinging data inconsistencies suggest previously developed model mek inhibitor suggest causes mechanistic modeling experimental data data comparison cell proliferation cell lineages 6 inhibitor work lays widely available treated conditions silico </ overall lack often muddled mammalian single lineage tracing induced signaling direct model detailed single death signaling death events critical determinant cellular heterogeneity cellular balance cancer drugs
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Workflow of the developed simulation algorithm.

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