Identification of canonical and non-canonical kinases in PI3K/AKT networks.

Identification of canonical and non-canonical kinases in PI3K/AKT networks.

<p>A. Kinase interactions of the selected communities in network AZD5363<sup>–</sup> . Abbreviations: SC; selected community. On the left hand side of panel A the nodes and edges within the community AZD5363<sup>–</sup><sub>(AKT1/2)</sub> are depicted, in wh...

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Bibliographic Details
Main Author:	Celia De Los Angeles Colomina Basanta (16437798) (author)
Other Authors:	Marya Bazzi (9331970) (author), Maruan Hijazi (16437801) (author), Conrad Bessant (2382658) (author), Pedro R. Cutillas (4257760) (author)
Published:	2023
Subjects:	Cell Biology Molecular Biology Immunology Developmental Biology Cancer Hematology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified drew similar insights acute myeloid leukaemia cells treated separately external phosphoproteomics dataset analyses returned communities network edges ), canonical signalling pathways used modularity maximisation signalling network circuitry community detection algorithms 000 phosphorylation sites aml cells treated empirical kinase networks phosphorylation sites community detection treat cells mtor signalling empirical cell detect communities ttk phosphorylation community containing study illustrates phosphoproteomics data mtor members mtor inhibitors main target likely component kinase relationships inhibitor used immune function erk inhibitors deriving knowledge define kinase challenging due cell growth canonical pi3k biological processes assess whether also known
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