Dependence of the heterogeneity of 3D genome model conformations on the model resolution.

<p>The conformations of the two chains of green beads – chromatin models at a high resolution – are very different. After coarse-graining (going to a lower resolution), the two chromatin chains now represented by white spheres look exactly the same.</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Samira Mali (8897903) (author)
مؤلفون آخرون:	Igor S. Tolokh (1314408) (author), Erik Cross (21656212) (author), Alexey V. Onufriev (430594) (author)
منشور في:	2025
الموضوعات:	Biophysics Genetics Biotechnology Cancer Hematology Plant Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified nuclear lamins leads significant differences arise relatively subtle differences approximately 14 kb increased structural heterogeneity given genomic separation genomic tad size chromatin structure might take experimental hi interphase x chromosome quantifying conformational heterogeneity larger genomic distances use bulk hi necessarily limited single div >< p chromatin models examined beyond 100 kb 3d genome organization conformational heterogeneity </ increasing model resolution 3d chromatin conformations conformational heterogeneity interphase chromatin bulk hi chromatin models major differences 2 kb genomic separations genomic distance cell heterogeneity models constructed cell hi work show third relies strongest near standard deviation single cells similar trend resolution limit potential implication modeling approaches model resolution loci distances little effect h .</ facilitate comparison ensemble distribution different resolutions damid data computational approach
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Dependence of the heterogeneity of 3D genome model conformations on the model resolution.

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