Clozapine inhibited cancerous growth of MCF-7 cells.

<p>(A) MCF-7 cells were seeded into 24-well plates at a density of 2 × 104 cells/well for 24h, followed by incubating with the indicated concentration of clozapine for 1 to 3 days. Cell proliferation was then measured using an MTT assay. (B) 500 cells were seeded in a 60 mm Petri dish and incu...

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Detalhes bibliográficos
Autor principal:	Ya-Chun Fan (21567690) (author)
Outros Autores:	Shih-Chao Lin (3753646) (author), Po-Jung Lai (630383) (author), Pei-Chun Lai (10132949) (author), Germain Maurus (21567693) (author), Shiow-Yi Chen (160980) (author)
Publicado em:	2025
Assuntos:	Biochemistry Cell Biology Molecular Biology Physiology Pharmacology Biotechnology Immunology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified western blotting analyses g1 phase arrest assess cell proliferation reduces cell viability induced cell death breast cancer cells term antipsychotic treatment ros ), apoptosis clozapine induces apoptosis reduces ros induced apoptosis antipsychotic drugs induced cytotoxicity similar ros ros plays ros generation induces autophagy used clonogenic upregulating p21 tumor effects therapeutic agent study investigates study demonstrates results show psychotic disorders psychiatric medication previous studies mtt assays flow cytometry findings suggest combining clozapine clozapine suppresses central role 231 cells
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Clozapine inhibited cancerous growth of MCF-7 cells.

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