Establishment of a Cochlear Organoid Platform for Remodeling the Extracellular Matrix

Irreparable injury and depletion of inner ear hair cells lead to permanent hearing impairment. Cochlear organoids serve as a robust <i>in vitro</i> platform for investigating the pathogenesis of deafness and exploring therapeutic approaches. However, the widely used commercial Matrigel i...

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Glavni avtor:	Nianci Li (6021555) (author)
Drugi avtorji:	Ziyu Zhang (3505355) (author), Liyan Zhang (322168) (author), Danqi Wu (21723049) (author), Zhe Li (219258) (author), Changling Xu (13116703) (author), Qiuhan Sun (21723052) (author), Yicheng Lu (124846) (author), Yinyi Zhou (20527523) (author), Xiaoyun Qian (5809400) (author), Yangnan Hu (6336341) (author), Fangzhi Tan (21723055) (author), Jieyu Qi (7105475) (author), Renjie Chai (276884) (author)
Izdano:	2025
Teme:	Biophysics Medicine Cell Biology Genetics Molecular Biology Physiology Biotechnology Developmental Biology Cancer Biological Sciences not elsewhere classified permanent hearing impairment exploring therapeutic approaches cochlear stem cells cochlear organoids serve cochlear hair cells cochlear organoid morphogenesis cochlear organoid generation cochlear organoid development organoid formation process mmps significantly interfered cochlear organoid platform mediated ecm remodeling organoid formation organoid self work provides vitro </ underwent rapid structural stability spontaneous clustering matrix metalloproteinases markedly upregulated issues related important role functional maturation extracellular matrix extensive remodeling early phase alternative approach
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Establishment of a Cochlear Organoid Platform for Remodeling the Extracellular Matrix

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