Small Molecule Drugs Triggered the Activation of Macrocycle Masked Proteins

Small Molecule Drugs Triggered the Activation of Macrocycle Masked Proteins

On-demand activation of prodrugs represents an emerging and fast developing strategy to improve the therapeutic index of certain drugs. However, strategies to generate protein-based prodrugs with controllable activation are still limited. Here, we present a supramolecular masking strategy that enabl...

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Bibliographic Details
Main Author: Zhiying Zeng (14755472) (author)
Other Authors: Wenkang Cai (5827796) (author), Yingze Liu (7596647) (author), Yeyu Su (19456634) (author), Yi Sun (118759) (author), Linzhi Tan (9142484) (author), Liying Chang (14619488) (author), Yu Liu (6938) (author), Yong Wang (12837) (author), Tao Liu (10785) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Molecular Biology
Pharmacology
Biotechnology
Cancer
Infectious Diseases
Chemical Sciences not elsewhere classified
terminal peptide motifs
incorporate two n
fast developing strategy
8 ]­ uril
generation protein therapeutics
supramolecular masking strategy
macrocycle masked proteins
masking strategy
supramolecular strategy
masked proteins
8 ])
supramolecular mask
therapeutic index
still limited
selectively reversed
protein activity
prodrugs represents
method provided
inhibitory effect
inhibiting interactions
including antibodies
generate protein
drug administration
certain drugs
based prodrugs
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