Small Molecule Drugs Triggered the Activation of Macrocycle Masked Proteins

On-demand activation of prodrugs represents an emerging and fast developing strategy to improve the therapeutic index of certain drugs. However, strategies to generate protein-based prodrugs with controllable activation are still limited. Here, we present a supramolecular masking strategy that enabl...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Zhiying Zeng (14755472) (author)
مؤلفون آخرون:	Wenkang Cai (5827796) (author), Yingze Liu (7596647) (author), Yeyu Su (19456634) (author), Yi Sun (118759) (author), Linzhi Tan (9142484) (author), Liying Chang (14619488) (author), Yu Liu (6938) (author), Yong Wang (12837) (author), Tao Liu (10785) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Medicine Molecular Biology Pharmacology Biotechnology Cancer Infectious Diseases Chemical Sciences not elsewhere classified terminal peptide motifs incorporate two n fast developing strategy 8 ] uril generation protein therapeutics supramolecular masking strategy macrocycle masked proteins masking strategy supramolecular strategy masked proteins 8 ]) supramolecular mask therapeutic index still limited selectively reversed protein activity prodrugs represents method provided inhibitory effect inhibiting interactions including antibodies generate protein drug administration certain drugs based prodrugs
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Small Molecule Drugs Triggered the Activation of Macrocycle Masked Proteins

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