Degradation leakage of the auxin-inducible degron is tissue-specific.

<p>A. Endogenous indole-3-acetate (IAA) concentrations measured by targeted metabolomics (LC-MS) analysis of ileum tissue homogenate from untreated mice [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011830#pgen.1011830.ref055" target="_blank&quo...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Gillian C. A. Taylor (3909568) (author)
مؤلفون آخرون:	Lewis Macdonald (22120476) (author), Natalia A. Szulc (12733802) (author), Evelina Gudauskaite (22120479) (author), Brianda Hernandez Moran (22120482) (author), Jennifer M. Brisbane (22120485) (author), Molly Donald (22120488) (author), Ella Taylor (22120491) (author), Dejin Zheng (22120494) (author), Bin Gu (223694) (author), Pleasantine Mill (256953) (author), Patricia L. Yeyati (22120497) (author), Wojciech Pokrzywa (37845) (author), Claudia Ribeiro de Almeida (16007018) (author), Andrew J. Wood (22120500) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Microbiology Genetics Molecular Biology Physiology Biotechnology Developmental Biology Cancer Inorganic Chemistry Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified one case (< mitotic cells via cause unwanted changes trigger protein degradation study protein functions div >< p terminal tag fusion dependent changes cultured cells tagged protein tag fusion protein tags protein stability protein expression genetic fusion widely used well known vivo </ underappreciated importance tir1 expression terminal auxin tag fusions stabilisation occurred small intestine results highlight reach levels particularly important occurred selectively ncaph2 </ inherent property inducible degron destabilisation resulted basal concentrations animal models acetic acid
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Degradation leakage of the auxin-inducible degron is tissue-specific.

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