The hypothesized acetogenic pathway in T. pallidum.

Relevant pathway enzymes are shown as ovals, with the enzyme that is featured in this work in purple. The equivalent of TP0476 in T. vincentii is TV0924 (not shown). Shaded yellow boxes depict flavoproteins, and cyan rectangles represent transmembrane p...

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Bibliographic Details
Main Author:	Ranjit K. Deka (15626723) (author)
Other Authors:	Shih-Chia Tso (3704401) (author), Wei Z. Liu (3044511) (author), Chad A. Brautigam (242609) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Genetics Molecular Biology Evolutionary Biology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified related treponemal species microaerophilic host environments cycle enzymes suggested alternative sources could evidence strongly supported treponema vincentii </ biochemical evidence supports second crystal structure named tp0476 ), div >< p acid sequence identity known acetate kinases alternative energy source treponema pallidum </ 3 å resolution biochemical evidence crystal structure energy source acetate kinases pallidum </ 36 å acetogenic energy acetate kinase sole carbon similar fold recent bioinformatic provided insight parasitic spirochete ostensibly catalyzes oral pathogen key component human disease homologous enzyme final enzyme enzyme ’ enzyme exists enzymatic activity
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The hypothesized acetogenic pathway in <i>T</i>. <i>pallidum</i>.

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