The hypothesized acetogenic pathway in T. pallidum.

Relevant pathway enzymes are shown as ovals, with the enzyme that is featured in this work in purple. The equivalent of TP0476 in T. vincentii is TV0924 (not shown). Shaded yellow boxes depict flavoproteins, and cyan rectangles represent transmembrane p...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ranjit K. Deka (15626723) (author)
مؤلفون آخرون:	Shih-Chia Tso (3704401) (author), Wei Z. Liu (3044511) (author), Chad A. Brautigam (242609) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Microbiology Genetics Molecular Biology Evolutionary Biology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified related treponemal species microaerophilic host environments cycle enzymes suggested alternative sources could evidence strongly supported treponema vincentii </ biochemical evidence supports second crystal structure named tp0476 ), div >< p acid sequence identity known acetate kinases alternative energy source treponema pallidum </ 3 å resolution biochemical evidence crystal structure energy source acetate kinases pallidum </ 36 å acetogenic energy acetate kinase sole carbon similar fold recent bioinformatic provided insight parasitic spirochete ostensibly catalyzes oral pathogen key component human disease homologous enzyme final enzyme enzyme ’ enzyme exists enzymatic activity
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الملخص:	<p>Relevant pathway enzymes are shown as ovals, with the enzyme that is featured in this work in purple. The equivalent of TP0476 in <i>T</i>. <i>vincentii</i> is TV0924 (not shown). Shaded yellow boxes depict flavoproteins, and cyan rectangles represent transmembrane proteins and complexes. The exception is the RNF complex, which is colored yellow to emphasize its status as a potential flavoprotein. The uncertain role of TP0038 in D-lactate import is noted with a question mark. The pink box labeled “C/O” encompasses proteins that ostensibly participate in the formation and utilization of the chemiosmotic gradient. The substrate-level phosphorylation putatively catalyzed by TP0476/TV0924 is in a light-blue box labeled “SLP.” Nu: nutrient; CM: cytoplasmic membrane; Fld: flavodoxin; D-LDH: D-lactate dehydrogenase; Pta: phosphotransacetylase; PFOR: pyruvate-flavodoxin oxidoreductase; RNF: <i>Rhodobacter</i> nitrogen fixation (RNF) complex, a Na<sup>+</sup>-translocating flavodoxin:NAD<sup>+</sup> oxidoreductase;. This figure was adapted (changes were made) from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0312642#pone.0312642.g001" target="_blank">Fig 1</a> in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0312642#pone.0312642.ref016" target="_blank">16</a>]. The license under which this was done is at <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a>.</p>

The hypothesized acetogenic pathway in <i>T</i>. <i>pallidum</i>.

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