Introduction of mutations in invariable regions (IR) of the central cassette of vlsE.

(A) A schematic representation of mutations generated in invariable regions of the central cassette of vlsE on the linear shuttle vector pBSV2rtel::vlsE. Alanine coded by 5’ GCT 3’ at positions 220 in IR4 (green) and 282 in IR6 (orang...

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Bibliographic Details
Main Author:	Preeti Singh (450793) (author)
Other Authors:	Troy Bankhead (70620) (author)
Published:	2025
Subjects:	Medicine Microbiology Genetics Evolutionary Biology Cancer Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified two decades ago specific mutations affecting raises intriguing questions previous observations suggesting manipulate genetically due dynamic evolutionary process div >< p creates new avenues central variable cassette lyme disease pathogen highly segmented pathogen potentially crucial role >- acting elements borrelia burgdorferi </ pathogen interactions represent host immune response gene conversion strategy trans vlse </ pathogen interactions vlse </ trans </ pivotal role genetic elements gene conversion vls </ cis </ systematic exploration study presents study highlights significant advancements proteins involved precise processes plasmid topology novel methods notoriously challenging mutational approach molecular biology linear plasmid genetic manipulation genetic engineering first time explore host direct manipulation could guide antigenic variation
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Introduction of mutations in invariable regions (IR) of the central cassette of <i>vlsE</i>.

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