Mutations within the conserved motif of Mcm3’s NLS impair cell growth.

<p>A) The conserved motif of Mcm3’s NLS resides in an unstructured region. Upper panel: Sequence alignment illustrates conservation of the Mcm3 sequences from K764 to R771 in fungi, with K767, K768, R769 and R771 also conserved in mouse and human. Lower panel: AlphaFold predicts that the conse...

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Bibliographic Details
Main Author:	Ziyi Wang (1956610) (author)
Other Authors:	Yun Jing Zhang (20592158) (author), Qian-yi Zhang (12867706) (author), Kate Bilsborrow (20592161) (author), Matthew Leslie (5010068) (author), Raymond T. Suhandynata (2805466) (author), Huilin Zhou (374813) (author)
Published:	2025
Subjects:	Medicine Cell Biology Genetics Molecular Biology Evolutionary Biology Cancer Virology Biological Sciences not elsewhere classified replicative dna helicase defective chromatin loading basic residues within basic amino acids single consensus sequence xlink "> proteins poor cell growth nuclear localization sequences universally conserved sequence analyzing monopartite nlss mcm3 </ p sequence specificity cell nucleus nuclear transport nuclear import sv40 large results provide precise positioning mcm complex importin proteins identifying nlss guided framework despite lacking conserved nls challenging due alphafold 3
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Mutations within the conserved motif of Mcm3’s NLS impair cell growth.

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