Polo-like kinase 1 (PLK1) induces Vemurafenib resistance in melanoma.

Polo-like kinase 1 (PLK1) induces Vemurafenib resistance in melanoma.

<p><b>(A)</b> Relative cell viability under the treatment of Vemurafenib in mouse melanoma cells (mMC) and mouse melanoma with Plk1 knock-in (mMPI) cells. <i>n</i> = 3 biological replicates. Mean ± SD. n.s., <i>P</i> > 0.05; * <i>P</i> < 0....

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Autor principal: Fengyi Mao (15073242) (author)
Altres autors: Sai Wu (6096290) (author), Derek B. Allison (15141675) (author), Daheng He (9189701) (author), Yifan Kong (4458616) (author), Chaohao Li (15141681) (author), Zhiguo Li (431917) (author), Yanquan Zhang (14930570) (author), Xinyi Wang (559030) (author), Qiongsi Zhang (2818111) (author), Chi Wang (131921) (author), Xiaoqi Liu (45630) (author)
Publicat: 2025
Matèries:
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Cancer
Hematology
Biological Sciences not elsewhere classified
suppress tumor growth
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crucial transcription factor
cnc homolog 1
clinical database analysis
shortened mice survival
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synergistic efficiency
novel function
negatively correlates
genes involved
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cancer progression
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