CMG2 receptor-dependent in vivo toxicity of anthrax edema toxin.

A. CMG2-KO mice and their littermate WT control mice were challenged with 20 µg ET (I.P.), and monitored for signs of malaise and survival for 200 hours. Log-rank test for survival comparison. B. ET-induced cAMP increases in mice. Eighteen hours after c...

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Bibliographic Details
Main Author:	Jie Liu (15128) (author)
Other Authors:	Qing Cao (417020) (author), Michael Ewing (518331) (author), Zehua Zuo (9525555) (author), Jason R. Kennerdell (15161565) (author), Toren Finkel (4068709) (author), Stephen H. Leppla (16310) (author), Shihui Liu (120192) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Physiology Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified major virulence factors chloride ions accompanied dependent adenylate cyclase bacillus anthracis </ activated pka phosphorylation another bacterial toxin elevates intracellular camp div >< p anthrax lethal toxin similar pathogenic mechanism pathogenic mechanism vivo </ dependent events pka ), anthrax pathogenesis anthrax disease toxin ’ edema toxin cholera toxin severe diarrhea protein kinase mediated pka intestinal lumen increases camp important role generally believed extensively studied data suggest converting atp certain camp causative pathogen atp depletion
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CMG2 receptor-dependent <i>in vivo</i> toxicity of anthrax edema toxin.

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