Structure basis and mechanism of action for the broadly neutralization by Tnb04-1.

a. Overall crystal structure of the Tnb04-1 (green), SARS-CoV-2 RBD (cyan), and 1F11 fab (yellow and pink) complex. b. The epitope and paratope of Tnb04-1, highlighted in light gray in the context of RBD (cyan) and Tnb04-1 (green) and the involved resid...

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Main Author:	Haodi Dong (4390237) (author)
Other Authors:	Runhong Zhou (9287894) (author), Jing Chen (4762) (author), Jing Wei (127335) (author), Zimeng Wei (8867858) (author), Ziqing Yang (11828318) (author), Kun Zhu (447919) (author), Yufan Yang (8250309) (author), Qianqian Yang (203850) (author), Na Liu (102929) (author), Yuting Chen (151583) (author), Yuhan Wu (5540507) (author), Yan Liang (139654) (author), Yige Zeng (20161341) (author), Qile Guo (11510104) (author), Mingxi Li (264917) (author), Sisi Shan (6738692) (author), Han Wang (254423) (author), Mengyue Niu (4816368) (author), Isabella Yunfei Zeng (20161344) (author), Xuanling Shi (84386) (author), Qi Zhang (28502) (author), Xinquan Wang (211905) (author), Zhiwei Chen (254191) (author), Linqi Zhang (350238) (author)
Published:	2024
Subjects:	Biophysics Microbiology Cell Biology Molecular Biology Evolutionary Biology Ecology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified spike &# 8217 conserved hydrophobic pocket combating respiratory acquisition authentic omicron xbb 1 holds promise potent neutralizing capabilities demonstrate exceptionally broad ace2 binding site 1 </ p sarbecoviruses including sars 2 subvariant kp 5 subvariant 1 emerges xlink "> urgent need super broad study highlights resistant core recently emerged proteinase k potential threat ongoing evolution intranasal administration interaction disrupts immunized alpacas immune escape effective strategies divergent sars cell fusion binding domain
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Structure basis and mechanism of action for the broadly neutralization by Tnb04-1.

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