B-JLF segmentation-based age-corrected effect sizes from SHARP+MEDI pipelines deemed acceptable in the replication study.

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• FIRST segmentation-based age-corrected effect sizes from SHARP+MEDI pipelines deemed acceptable in the replication study.
  by: Fahad Salman (6150395)
  Published: (2025)
• Regularization parameters (λ) used for the QSM algorithms. For the sophisticated harmonic artifact reduction for phase (SHARP) and morphology enabled dipole inversion (MEDI) algorithms, only the parameters deemed acceptable in the replication study are listed, which were used in this study. Variable radius SHARP (VSHARP); Regularized Enabled SHARP (RESHARP).
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• For SHARP+MEDI pipelines, median percentage difference in effect sizes from (a) different reference regions with FMRIB’s Integrated Registration and Segmentation Tool (FIRST) segmentation, relative to the originally used frontal deep white matter (FDWM) reference region, and (b) the Bi-parametric Joint Label Fusion (B-JLF) segmentation method, both across all reference regions (All) and individually for each reference region (FDWM, whole brain [WB], and cerebrospinal fluid [CSF]), relative to FIRST and their respective counterparts.
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• Susceptibility maps in native space of a representative subject (38 years old female; RMS patient [EDSS = 0]) from additional inversion algorithms (listed at the bottom; Approximate Message Passing with Parameter Estimation [AMPPE], Least Squares QR [LSQR], Homogeneity Enabled Incremental Dipole Inversion [HEIDI], respectively) across all BFR algorithms (listed on the left-hand side with their respective regularization parameters [λ]; Sophisticated Harmonic Artifact Reduction for Phase [SHARP, λ_S]; Variable radius SHARP [VSHARP, λ_V] and Regularized Enabled SHARP [RESHARP, λ_R], respectively).
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• Background field-corrected field maps in native space of a representative subject (38 years old female; RMS patient [EDSS = 0]) from additional BFR algorithms (listed on the left-hand side; Variable radius [V] Sophisticated Harmonic Artifact Reduction for Phase [SHARP; VSHARP] and Regularized Enabled SHARP [RESHARP], respectively) over a range of alternative λ values (listed at the top [λ_V] and bottom [λ_R], respectively).
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  Published: (2025)