Proteoform-predictor: Increasing the Phylogenetic Reach of Top-Down Proteomics

Proteoform-predictor: Increasing the Phylogenetic Reach of Top-Down Proteomics

Proteoforms are distinct molecular forms of proteins that act as building blocks of organisms, with post-translational modifications (PTMs) being one of the key changes that generate these variations. Mass spectrometry (MS)-based top-down proteomics (TDP) is the leading technology for proteoform ide...

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Bibliographic Details
Main Author: Taojunfeng Su (6426218) (author)
Other Authors: Ryan T. Fellers (1306392) (author), Joseph B. Greer (1325640) (author), Richard D. LeDuc (1319583) (author), Paul M. Thomas (548327) (author), Neil L. Kelleher (548328) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Genetics
Evolutionary Biology
Developmental Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
three bacterial strains
searching ms data
distinct molecular forms
demonstrated significant improvement
transferring ptm sites
limited ptm annotations
comprehensive ptm characterization
diverse species across
tdp technology advances
proteoform identification due
subsequent tdp analysis
proteoform database creation
ptm biology
proteoform identification
leading technology
characterized species
proteoform candidates
developed proteoform
wide range
variant sequences
translational modifications
tool features
source tool
reference proteome
phylogenetic tree
mass spectrometry
key changes
intuitive workflow
integrates homology
important tool
homologous sequences
friendly interface
crucial step
building blocks
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