Toward the Design of Allosteric Effectors: Gaining Comprehensive Control of Drug Properties and Actions

While the therapeutic potential of allosteric drugs is increasingly realized, the discovery of effectors is largely incidental. The rational design of allosteric effectors requires new state-of-the-art approaches to account for the distinct characteristics of allosteric ligands and their modes of ac...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Wei-Ven Tee (5410859) (author)
مؤلفون آخرون:	Sylvester J. M. Lim (19747509) (author), Igor N. Berezovsky (10586196) (author)
منشور في:	2024
الموضوعات:	Biophysics Medicine Genetics Pharmacology Computational Biology Biological Sciences not elsewhere classified precision medicine approach gaining comprehensive control generic framework proposed g12d </ sup distinct functional sites functional site framework using distinct characteristics binding sites tunable regulation throughput per therapeutic potential switch regions specific signaling residue quantification providing targeted optimized simultaneously main protease largely incidental known well increasingly realized highly specific drug properties characterized drugs art approaches allosteric signaling allosteric ligands allosteric drugs achieve targeted
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Toward the Design of Allosteric Effectors: Gaining Comprehensive Control of Drug Properties and Actions

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