Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements

Microplastics are emerging contaminants that pose health risks. They can cause hepatic lipid interventions, but the underlying mechanisms require investigation. This study assessed the retention of polypropylene microplastics in mouse liver and determined the intercorrelations between hepatic lipid...

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Autor principal:	Miao Wang (248377) (author)
Altres autors:	Jing Wang (6206297) (author), Xinglin Sun (22522424) (author), Kena Zhang (289068) (author), Jing Gao (69330) (author), Xiaoying Xu (491572) (author), Jiarui Wu (149317) (author), Fangfang Tao (408131) (author), Dayi Zhang (648810) (author), Mingying Liu (130096) (author)
Publicat:	2025
Matèries:	Biochemistry Cell Biology Genetics Molecular Biology Physiology Biotechnology Cancer Infectious Diseases Computational Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified various stimuli response ultrastructural mitochondrial abnormalities trna methyltransferase (< pose health risks multicellular organism development mitochondria translation modulation induced lipidomic fluctuations liver molecular landscape liver biomolecule landscapes induced liver dysfunction cell fate monitor mitochondria transcription (< lipid metabolic process hepatic lipid fluctuations >( bbc3 </ mitochondrial protein translation energy disarrangements microplastics >), cell differentiation cell differentiation mouse liver mrna transcription lipid metabolism lipid biomarkers energy imbalance trmt112 </ mrps12 </ mrpl53 </ lrrc15 </ lipg </ gdf15 </ etnppl </ transcriptomic changes study assessed significant consequences signal transduction redox state raman peak raman biospectra profound effects polypropylene microplastics mainly involved intimately connected gene expressions findings suggested expression regulation exposure duration emerging contaminants chronic high cholesterol metabolism aggregated forms
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Molecular Landscape Remodeling Unravels the Cross-Links of Microplastics-Induced Lipidomic Fluctuations, Nutrient Disorders and Energy Disarrangements

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