Overview of predictive modelling for RNA Pol-II occupancy.

<p>(A) Schematic of the multilayer perceptron (MLP) model architecture used to predict RNA Pol-II occupancy based on chromatin-associated protein profiles. Input features include protein occupancy data from ChIP-seq experiments, and outputs represent predicted RNA Pol-II occupancy. (B) Model p...

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Bibliographic Details
Main Author:	Kashyap Chhatbar (9515350) (author)
Other Authors:	Adrian Bird (84938) (author), Guido Sanguinetti (343362) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures
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Overview of predictive modelling for RNA Pol-II occupancy.

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