Overview of predictive modelling for RNA Pol-II occupancy.

<p>(A) Schematic of the multilayer perceptron (MLP) model architecture used to predict RNA Pol-II occupancy based on chromatin-associated protein profiles. Input features include protein occupancy data from ChIP-seq experiments, and outputs represent predicted RNA Pol-II occupancy. (B) Model p...

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Main Author: Kashyap Chhatbar (9515350) (author)
Other Authors: Adrian Bird (84938) (author), Guido Sanguinetti (343362) (author)
Published: 2025
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Summary:<p>(A) Schematic of the multilayer perceptron (MLP) model architecture used to predict RNA Pol-II occupancy based on chromatin-associated protein profiles. Input features include protein occupancy data from ChIP-seq experiments, and outputs represent predicted RNA Pol-II occupancy. (B) Model performance for predicting RNA Pol-II occupancy based on chromatin-associated protein profiles across datasets. Coefficients of determination (<i>R</i><sup>2</sup>) are shown for training, validation and test datasets for 5 splits.</p>