Estimated MSE of significant SNPs at threshold 5 × 10−4 for each method and pruned data set.

The darker green bar and dashed black line represent the average bias of the naïve approach. (TIFF)

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Bibliographic Details
Main Author:	Amanda Forde (5078099) (author)
Other Authors:	Gibran Hemani (208828) (author), John Ferguson (79508) (author)
Published:	2023
Subjects:	Genetics Biotechnology Sociology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified ‘ winnerscurse ’ winner &# 8217 upward bias present simulated data sets three different traits identify genomic variants gwas summary statistics div >< p improve existing methods wide association studies wide variety complex traits variants tend significant variants correction methods compare methods adjustment methods widely observed statistical corrections significant snps review existing results indicate r package phenomenon known perform poorly parametric bootstrap novel approach method assessment make adjustments first using competitive performance association estimates
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Estimated MSE of significant SNPs at threshold 5 × 10<sup>−4</sup> for each method and <i>pruned</i> data set.