Phosphatase PP2A promotes RTA dephosphorylation at Thr42 and Thr678 to suppresses the transactivation activity of RTA.

(A) Phosphatase PP2A agonist Forskolin suppresses the transcription activity of RTA. (B) Phosphatase PP2A inhibitor LB-100 promotes the transcription activity of RTA. For A and B, HEK293T cells were transfected with ORF57 (left) or PAN (right) reporter...

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Главный автор:	Lei Bai (631944) (author)
Другие авторы:	Lianghui Dong (7908431) (author), Jiazhen Dong (595963) (author), Xiaowei Liang (4721025) (author), Jiangwei Peng (21524781) (author), Yuncai Chen (7541564) (author), Xiaoyi Sun (2323519) (author), Yuting Chen (151583) (author), Xintong Li (3110796) (author), Hua Cai (15034) (author), Jing Huang (41604) (author), Zixu Cao (22772675) (author), Ke Lan (232754) (author)
Опубликовано:	2025
Предметы:	Biochemistry Microbiology Cell Biology Molecular Biology Evolutionary Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified provide new insights new binding partner human &# 947 host antiviral mechanism scaffold protein ppp2r1a promote ppp2r1a degradation initiating lytic replication kshv progeny virions viral lytic replication lytic replication ppp2r1a overexpression encoded replication viral latency transcription factor transcription activity transcription activator taken together proteasome pathway pharmacological agonist next demonstrated life cycle fully elucidated extensive studies central role
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Phosphatase PP2A promotes RTA dephosphorylation at Thr42 and Thr678 to suppresses the transactivation activity of RTA.

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